Correlates of immunity in SARS-CoV-2 post-vaccine infections in the Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) Study
نویسندگان
چکیده
Abstract Background: We sought to determine pre-infection correlates of immunity against SARS-CoV-2 post-vaccine infections. Methods: Serum and saliva samples from 176 BNT162b2-vaccinated adults in the Prospective Assessment Seroconversion study were collected between October December 2021 assessed for serum levels WT Spike (S)-specific IgG IgA antibodies using a microsphere-based multiplex immunoassay. also neutralization activity D614G, Delta (617.2), Omicron BA.1 BA.1.1 variants lentiviral pseudovirus assay. After fall visit, participants reported all positive PCR and/or antigen tests SARS-CoV-2. Duration, severity, type symptoms, as well risk exposures adherence precautionary measures, by questionnaires during spring 2022 visit. Results: Thirty-two (18.2%) had infections 7, April 1, 2022. Pre-infection anti-S antibody neutralizing titers higher individuals that did not develop infection (p values 0.0098, 0.0313, 0.021, respectively). No with an level greater than 15,000 binding units (BAU/ml) developed infection. Conclusion: High levels, high subvariants, low home scores correlated protection initial wave. BAU associated complete This work was supported whole, or part, federal funds Defense Health Program (HU00012020067, HU00012020094) Immunization Healthcare Branch (HU00012120104) Agency, United States Department Defense, National Institute Allergy Infectious Disease (HU00011920111), under Inter-Agency Agreement Y1-AI-5072.
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.159.02